By train:

From Paris - Gare de Lyon- several daily TGV (high speed train) reach Beaune or Chalon sur Saône (2hrs 10 min)

By car:

From Paris:

Highway- Autoroute A6. Direction Lyon. Then you have 3 possibilities:

1) Exit at Beaune (approx. 3 hrs 30 min)
Take D973, direction Autun (25 min)

2) Exit at Pouilly en Auxois (3 hrs 15 min)
Take N81, direction Arnay le Duc. Then N6 direction Chalon sur Saône/ Lyon (40 min)

3) Exit Chalon Nord. (3 hrs 45 min)
Take N6 Direction Paris. (30 min)

By the Nationale N6, if you wish to see the country.